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KMID : 1098420070150030170
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 3 p.170 ~ p.176
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Comparison of Immune modulatary and Anticancer Activities according to the Parts of the Styrax japonica Sieb. et Zucc.
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Kwon Oh-Woung
Kim Cheol-Hee
Kim Hyo-Sung
Kwon Min-Cheol
Ahn Ju-Hee
Lee Hak-Ju
Kang Ha-Young
Lee Hyeon-Yong
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Abstract
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This study was performed to anticancer activities and immune modulatary activities according to the parts of the S. japonica Sieb. et Zucc. The cytotoxicity on human kidney cell (HEK 293) was showed below 27.4% in adding the methanol extracts. The anticancer activity were increased in over 60% by barks extracts in AGS and MCF-7 cells. The immune cell growth using human immune B and T cells was improved by the barks extracts of S. japonica Sieb. et Zucc. in adding 1.0mg/ml concentration. The secretion of the IL-6 and TNF-{alpha} from human immune B and T cells was showed secretion for the amount of cytokines by bark extracts of S. japonica Sieb. et Zucc. NK cell growth was increased against control all of the extracts of S. japonica Sieb. et Zucc. Densitometric analysis of Bcl-2 revealed that possible to decrease potentialities of taking cancer in adding of extracts from S. japonica Sieb. et Zucc. From the results, the roots and barks extracts of S. japonica Sieb. et Zucc. were showed useful biological activities.
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KEYWORD
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Styrax japonica, Anticancer activities, Bcl-2, Immune activity, Cytokine, NK cell
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